Advance-CTR Grant Resubmission Awards (2017)
"Role of Skeletal Muscle Mitochondrial Supercomplexes in Exercise Intolerance"
Pulmonary hypertension is associated with poor quality of life, impaired functional tolerance and limitation in physical activity. Results from these studies will establish the important role of changes in the organization of muscle energy producing proteins known as mitochondrial supercomplexes in exercise intolerance. These studies will lay the foundation for new areas of investigation (including novel drug therapies) to target mitochondrial supercomplexes in physical rehabilitation of veterans with medical co-morbidities.