Advance-CTR Grant Resubmission Awards (2017)
"Dynamic Regulation of the Ovarian Reserve"
Primary ovarian insufficiency (POI) affects approximately 1% of women worldwide and results in premature ovarian aging and early menopause. We have discovered that TAF4b-deficient mice undergo many of the hallmarks of human POI including defective meiotic development, increased primordial follicle attrition, elevated gonadotropins and female infertility. By elucidating the molecular mechanisms of TAF4b in the regulation of the establishment of the ovarian follicle reserve in the mouse, we will increase our fundamental understanding of the mechanisms that regulate the establishment and maintenance of the human ovarian reserve, thereby increasing our understanding and potential ways to better manage POI in women.